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The cheapest and fastest trains from Milan to Isernia
Showing times and prices for 21 Dec
Cheapest price
£72
Average price
£78
Fastest journey
4 h 50 m
Average duration
8 h 57 m
Trains per day
3
Distance
592 km
Cheap tickets
The best way to find a cheap train ticket from Milan to Isernia is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from Milan to Isernia will cost around £78 if you buy it on the day, but you can find cheap train tickets today for only £72.
Fast trains
Of the 3 trains that leave Milan for Isernia every day 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
These direct trains cover the 592 km distance in an average of 8 h 57 m but if you time it right, some trains will get you there in just 4 h 50 m .
The slowest trains will take 11 h 20 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
06:4011h20
Milan18:00Isernia
£721One-way
0 changes
04:0510h42
Milan14:47Isernia
£731One-way
0 changes
15:254h50
Milan20:15Isernia
£881One-way
0 changes
15:254h50
Milan20:15Isernia
£881One-way
0 changes
04:0510h42
Milan14:47Isernia
£731One-way
0 changes
06:4011h20
Milan18:00Isernia
£721One-way
0 changes
Travel Information
Compare coach, train and flight for Milan to Isernia
Omio recommends booking the train as it is the most popular option from Milan to Isernia among Omio's users. If you are prioritising price take the coach with prices starting from £31. For those with little time consider booking a flight which can get you there in 1h 13m. The ticket price range depends on the travel mode: a coach costs an average of £31, and a flight costs an average of £23.
Distance: 592 km
Compare train with
Most popular Train | Coach | Flight |
|---|---|---|
£62 Average Price | £52 Average Price Cheapest | £64 Average Price |
9h 29m Average total duration 8h 59m Onboard + 30m Additional time* | 9h 57m Average total duration 9h 27m Onboard + 30m Additional time* | 4h 13m Average total duration Fastest 1h 13m Onboard + 3h 0m Additional time* |
 Most popular train company |  Most popular bus company |  Most popular airline |
Direct Options | Direct Options | Direct Options |
Live departures
Milan to Isernia train times
The table below shows live departures for Milan to Isernia trains for today, Saturday 20 December. You can also manually refresh the results below to see updated train journeys.
Last updated at 06:19
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
| 19:10 Milan | 11h19 | 06:29 Isernia | 0 changesdirect | |
| Sunday 21 December | |||||
| 04:05 Milan | 10h42 | 14:47 Isernia | 0 changesdirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Milan to Isernia by coach, train or flight
Compare coach, train and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sun
21 Dec
21 Dec
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22 Dec
22 Dec
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23 Dec
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27 Dec
27 Dec
Journey information
Overview: Train from Milan to Isernia
ItalyItaly
Trains from Milan to Isernia run on average 11 times per day, taking around 8h 59m. Cheap train tickets for this journey start at £33 but you can travel from only £23 by flight.
The earliest train runs at 04:40, the last at 22:45. The fastest train covers the 592 km distance in 4h 23m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from £23
Distance 592 km |
Average train duration 8h 59m |
Cheapest ticket price £33 |
Trains per day 11 |
Fastest train 4h 23m |
First train 04:40 |
Last train 22:45 |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from £23
Train companies: Frecciarossa, Italo, Intercity, Intercity Notte from Milan to Isernia trainsFrecciarossa, Italo, Intercity, Intercity Notte trains will get you between Milan and Isernia from £23. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Frecciarossa
About
Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.
Luggage & cancellation policy
Average Duration
6h 25m
Cheapest Price
£64
Frecciarossa frequency
9 a day
Luggage included
1 carry-on bag and 1 suitcase per passenger
Luggage storage
Overhead racks, dedicated luggage areas at carriage ends, under seats
Cancellation Policy
Refund policy depends on ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class
Seat reservation
Included in Executive class, optional fee for other classes
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free
Quiet zone
Italo
About
Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.
Luggage & cancellation policy
Average Duration
4h 50m
Cheapest Price
£59
Italo frequency
7 a day
Luggage included
2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
Cancellation possible according to ticket conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes
Seat reservation
Included in Prima and Club Executive. Optional extra cost in Smart and Comfort
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free
Quiet zone
Intercity
About
Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.
Luggage & cancellation policy
Average Duration
10h 25m
Cheapest Price
£33
Intercity frequency
2 a day
Luggage included
2 pieces of luggage up to 30kg total
Luggage storage
Overhead racks and designated luggage areas at end of carriages
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.
Seat reservation
Seat reservation included in ticket price for most routes
Toilets
USB plugs
Accessibility
Wheelchair spaces and accessible toilets available
Pets
Small pets in carriers allowed free, larger dogs require paid ticket
Quiet zone
Intercity Notte
About
Intercity Notte is an Italian train service operated by Trenitalia. It runs overnight services between major cities in Italy, making it a great option for travelers looking to save time and money. The Intercity Notte offers two types of trains: the Frecciarossa Notte and the Frecciargento Notte. The Frecciarossa Notte is the fastest train, with speeds of up to 300 km/h, while the Frecciargento Notte is slightly slower but still offers a comfortable journey. Both trains offer a range of onboard facilities, including comfortable seating, air conditioning, and Wi-Fi. Trenitalia offers a range of ticket types, including Standard, Comfort, and Business. Standard tickets are the most affordable, while Comfort and Business tickets offer additional benefits such as priority boarding and access to the lounge. The most popular routes for Intercity Notte are Rome to Milan, Rome to Venice, and Milan to Venice. These routes offer travelers the chance to explore some of Italy's most iconic cities in a convenient and comfortable way.
Luggage & cancellation policy
Average Duration
13h 25m
Cheapest Price
£71
Intercity Notte frequency
1 a day
Luggage included
1 handbag and 1 suitcase included in ticket price
Luggage storage
Luggage racks above seats and at carriage ends
Cancellation Policy
Cancellation possible according to ticket type conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full dining service and bar
Seat reservation
Seat reservation included in ticket price
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for disabled passengers
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs free.
Quiet zone
FAQs: Milan to Isernia train
Find answers to the most common questions about traveling from Milan to Isernia by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.
The train distance from Milan to Isernia is 592 km.
A visit of 2 to 3 days in Isernia is generally sufficient to explore its historical sites, enjoy local cuisine, and experience the town's cultural atmosphere.
The train journey from Milan to Isernia covers a distance of 592 km and takes approximately 4h 23m. Trains run 11 per day.
The train journey from Milan to Isernia offers a mix of urban and rural landscapes. Travellers can enjoy views of the Lombardy countryside, the rolling hills of Emilia-Romagna, and the Apennine Mountains, providing a scenic experience as the train travels south.
The first train from Milan to Isernia leaves at 4:40.
The last train from Milan to Isernia departs at 22:45.
Trains from Milan to Isernia run approximately 11 times per day.
Yes, there is a direct train between Milan and Isernia. The service operates 0 times per day, provided by Italo.
Yes, there is a high-speed train service from Milan to Isernia.
A day trip from Milan to Isernia is not feasible as the journey takes 4h 23m. Additionally, the distance is 592 km. However, there are 11 trains per day on this route.
To get from Milan to Isernia, you can choose from several travel options including coach, train and flight.
Booking trains from Milan to Isernia in advance is advisable, especially during peak travel seasons or for long journeys, to ensure availability and secure better fares.
Yes, there is a night train from Milan to Isernia.
The cost of a train ticket from Milan to Isernia can vary. The cheapest tickets are usually available from £33, while the average price tends to be around £62.
The cheapest way to get from Milan to Isernia is by flight, costing approximately £23.
The train station in Milan that goes to Isernia is Milan Centrale, and it arrives at Isernia station.
Yes, you can take the train from Milan to Isernia.
popular train stations
Important Stations and Airports in Milan and Isernia
Milan
Isernia
The major train station for departures in Milan is Milano Centrale. Find all the information you need to know about services, amenities and connections at Milano Centrale for your trip from Milan to Isernia.
Amenities at train station
Wifi
Lockers
Parking
Dining
ATM
Taxis
Accessibility
WC
Hotel
Ticket Office
Bike Parking
Bike Rental
Car Rental
Information Deskinformation
Ticket Office Hours
- Mon - Sun: 05:50 - 22:20
Distance to city center
2 kmWifi
- Free WiFi in the station.
Lockers
- Provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.
Dining
- Venchi
- Panzera Coffee
- Burger King
- Bar Motta
- Caffè Napoli
- VyTA Boulangerie
- Spontini
- Starbucks
- Dispensa Emilia
- McDonald's
- & many more
Accessibility
- Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.
Hotel
- Glam Hotel Milano
- NYX MIlan
- iQ Hotel Milano
Ticket Office
- Mon - Sun: 05:50 - 22:20
Information Desk
- Located next to the ticket office on the ground floor in the shopping gallery.
Public transport options for Milano Centrale
- Metro lines: M2 (green), M3 (yellow)
- Tram lines: 1
- Bus lines: 5, 9, 10, 42, 81, 87, 152, 728, N26, NM2, NM3, Air Bus, Orio Shuttle
- Train lines: FR, FB, EC, Thello, XP2, R28, IC, ICN, RV, R, Regio, Italo
Amenities at train station
WifiLockersParkingDiningATMTaxisAccessibilityWCHotel
Lost and Found OfficeTicket OfficeBike ParkingCar RentalInformation Desk
Luggage Cartsinformation
Ticket Office Hours
- 6:00 AM - 10:00 PM Monday - Sunday
Distance to city center
5 km
Number of platforms
8Wifi
- Free
Parking
- The car park is open 7 days a week, 24 hours a day. Access is available from Via G Battista Cassinis.
Dining
- Ristorante Pizzeria Il Moro
- Osteria La Piola
Taxis
- Outside the main entrance.
Accessibility
- Elevators, ramps.
WC
- €1
Hotel
- Starhotels Business Palace
- Hotel Mistral
- Hotel Brenta Milano
Lost and Found Office
- Located in the main hall
Car Rental
- Avis
Information Desk
- Located in the main hall
Luggage Carts
- Free
Station Plan
- Hall 1: main entrance, platforms 1-8 for trains to various destinations
- Hall 2: metro connections
Public transport options for Milano Rogoredo
- Metro: Line M3
- Bus: Several lines available
- Train: Regional and high-speed services
Amenities at train station
WifiParkingDiningATMTaxisAccessibilityWCHotelBike ParkingBike Rentalinformation
Distance to city center
2 kmWifi
- Free Wi-Fi in the station.
Dining
- Caffeteria Panni Caldi
- Princi
- Burgez
- Bricco Café
- U! Come tu mi vuoi
- Autogrill
- Culto
Accessibility
- Accessible facilities such as ticket machines, toilets, and ramps and additional assistance as needed from 07:45 to 22:30.
Hotel
- Hotel NH Milano Palazzo Moscova
- AC Hotel by Marriott Milano
- Tocq Hotel
Public transport options for Milano Porta Garibaldi
- Metro lines: M2, M5
- Bus lines: 43, 56, 70, 94
- Train lines: R21, R31, S1, S11, S2, S5, S7, S8
The major train station for arrivals in Isernia is Isernia. Find all the information you need to know about services, amenities and connections at Isernia for your journey to Isernia from Milan.
Amenities at train station
WifiLockersParkingDiningTaxisAccessibilityWCHotelLost and Found OfficeTicket OfficeBike ParkingInformation DeskLuggage Cartsinformation
Ticket Office Hours
- 6:00 AM - 8:00 PM Monday - Sunday
Number of platforms
2Wifi
- Free
Parking
- Parking is available 24/7 with access from Via Giovanni XXIII.
Dining
- Pasta e Pizza
- Ristorante da Adriano
Taxis
- Outside the main entrance.
Accessibility
- Ramps.
WC
- €0.50
Hotel
- Grand Hotel Europa
- Hotel Ristorante Sayonara
- Hotel La Tequila
Lost and Found Office
- Located in the main hall
Information Desk
- Located in the main hall
Luggage Carts
- Free
Station Plan
- Hall 1: main entrance, ticket office, and waiting area
- Hall 2: platforms for regional trains
Public transport options for Isernia
- Bus: Several local lines available
- Train: Regional connections
More options for your journey from Milan to Isernia
Here are some other resources that might have the information you need
Most popular trains to and from Isernia and Milan
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