Travel Information
Compare coach and flight for Santander to Brussels
Omio recommends booking the flight as it is the most popular option from Santander to Brussels among Omio's users. If you are prioritising price, take the coach, with an average ticket price of £14 For those with little time, consider booking a flight, which has an average total journey time of 5h 24m. Average ticket prices depend on the travel mode: a coach costs an average of £14, while a flight costs an average of £307.
Distance: 1026 km
Compare flight with
Most popular Flight | Coach | Driving |
|---|---|---|
£307 Average Price | £14 Average Price Cheapest | £192 Average Price (fuel + tolls) |
5h 24m Average total duration Fastest 3h 24m Onboard + 2h 0m Additional time* | 19h 21m Average total duration 18h 51m Onboard + 30m Additional time* | 13h 18m Average total duration (door-to-door) |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santander to Brussels:
A coach is £364 less than a flight for this route with tickets for a flight from Santander to Brussels costing on average £378.
Other travel options to Brussels take longer:
Coach takes on average 19h 21m.
You'll arrive about 9h 44m sooner (3h 34m by flight vs 13h 18m by car). Tickets start at around £378 compared to roughly £192 in fuel and tolls — a bit more, but you get time back and avoid a long drive.
Driving makes more sense if you're travelling as a group, want flexibility on timing, or plan to stop en route.
Travel optionsfrom Santander to Brussels
How to get to Brussels from Santander by train, bus, flight or ferry.
Our recommendation
The best way to travel from Santander to Brussels is by taking a coach because it’s the best combination of price and speed.
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4761 · 143320:4520h45Santander, Estación de Autobuses17:30Brussels, Brussels South (Gare du Midi)£481One-way2 changes
Cheapest
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4761 · 143320:4520h45Santander, Estación de Autobuses17:30Brussels, Brussels South (Gare du Midi)£481One-way2 changes
Fastest
FlixBus · FlixBus18:5018h50Santander, Estación de Autobuses13:40Brussels, Brussels South (Gare du Midi)£901One-way1 change
Other options
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4761 · 143320:2021h10Santander, Estación de Autobuses17:30Brussels, Brussels South (Gare du Midi)£481One-way2 changes
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4761 · 143319:3022h00Santander, Estación de Autobuses17:30Brussels, Brussels South (Gare du Midi)£481One-way2 changes
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4761 · 143318:4022h50Santander, Estación de Autobuses17:30Brussels, Brussels South (Gare du Midi)£481One-way2 changes
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, coaches, flights and ferries
Compare coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Santander to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Santander to Brussels.

This is compared to other travel options from Santander to Brussels:
A coach is £294 less than a flight for this route with tickets for a flight from Santander to Brussels costing on average £307.
Other travel options to Brussels take longer:
Coach takes on average 19h 21m.
- Around 31 coaches per day.
- Around 8 flights per day.
However, we recommend checking specific travel dates for your route between Santander and Brussels as scheduled services by coach and flight can vary by season or day of the week.
- Flights mostly depart from Santander Airport and arrive in Brussels Airport.
- Coaches mostly depart from Santander, Estación de Autobuses and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with BlaBlaCar Bus, FlixBus to go to Brussels by coach.
- Travel with Ryanair, Vueling, Iberia, Malta Air to go to Brussels by flight.
- 1 direct flights per day with Ryanair.
Travelling from Santander to Brussels: related information
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