Travel optionsfrom Panama City to Madrid
How to get to Madrid from Panama City by train, bus, flight or ferry.
Our recommendation
The best way to travel from Panama City to Madrid is by taking a flight because it’s the best combination of price and speed.
IB338+
IB436913:1616h34Panama City12:50Madrid Barajas Airport£5821One-way1 change
Cheapest
IB338+
IB436913:1616h34Panama City12:50Madrid Barajas Airport£5821One-way1 change
Fastest
UX5620:259h50Panama City13:15Madrid Barajas Airport£6731One-way0 changes
Other options
IB25821:0510h05Panama City14:10Madrid Barajas Airport£7071One-way0 changes
AA2964 · AA6813:1613h29Panama City9:45Madrid Barajas Airport£7381One-way1 change
AA2964+
AA874013:1616h34Panama City12:50Madrid Barajas Airport£7381One-way1 change
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Panama City to Madrid
Travel to Madrid easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Panama City to Madrid.

- Around 47 flights per day.
However, we recommend checking specific travel dates for your route between Panama City and Madrid as scheduled services by flight can vary by season or day of the week.
- Flights mostly depart from Panama City and arrive in Madrid Barajas Airport.
- Travel with Delta Air Lines, American Airlines, Lufthansa, Avianca, United, Air Europa, British Airways, Air France, KLM, Iberia to go to Madrid by flight.
- 2 direct flights per day with Air Europa, Iberia.
Travelling from Panama City to Madrid: related information
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