The cheapest and fastest trains from Venice Mestre to Siena station
Cheapest price
£34
Average price
£54
Fastest journey
3 h 58 m
Average duration
3 h 59 m
Trains per day
21
Distance
250 km
The best way to find a cheap train ticket from Venice Mestre to Siena station is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from Venice Mestre to Siena station will cost around £54 if you buy it on the day, but you can find cheap train tickets today for only £34.
To travel from Venice Mestre to Siena station you need to make at least one change.
Regionale Veloce 3961+
Intercity 583+
Regionale 18209
Regionale Veloce 3985+
Intercity 599+
Regionale 18233
Regionale Veloce 3977+
Intercity 597+
Regionale 18225
Intercity 584+
Regionale Veloce 4043 · Regionale 18851
Intercity 584+
Regionale 18223
FRECCIAROSSA 1000 9409+
Regionale 18209
FRECCIAROSSA 1000 9415+
Regionale 18217
FRECCIAROSSA 9421+
Regionale 18221
FRECCIAROSSA 9401+
Regionale 18203
FRECCIAROSSA 1000 9427+
Regionale 18225Travel Information
Compare coach and train for Venice Mestre to Siena station
Omio recommends booking the train as it is the most popular option from Venice Mestre to Siena station among Omio's users. If you are prioritising price take the coach with prices starting from £6. For those with little time consider booking a train which can get you there in 4h 4m. The ticket price range depends on the travel mode: a coach costs an average of £6, and a train costs an average of £20.
Distance: 250 km
Compare train with
Most popular Train | Coach |
|---|---|
£32 Average Price | £13 Average Price Cheapest |
4h 34m Average total duration Fastest 4h 4m Onboard + 30m Additional time* | 5h 11m Average total duration 4h 41m Onboard + 30m Additional time* |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Live departures
Venice Mestre to Siena station train times
The table below shows live departures for Venice Mestre to Siena station trains for today, Sunday 22 February. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
![]() | 21:17 Venice Mestre | 9h11 | 06:28 Siena station | 0 changesdirect | |
| Monday 23 February | |||||
FRECCIAROSSA 9401+ Regionale 18203 | 04:38 Venice Mestre | 4h00 | 08:38 Siena station | 1 change | |
Regionale Veloce 3961+ Intercity 583+ Regionale 18209 | 04:53 Venice Mestre | 6h45 | 11:38 Siena station | 2 changes | |
FRECCIAROSSA 9403+ Regionale 18205 | 05:38 Venice Mestre | 4h02 | 09:40 Siena station | 1 change | |
FRECCIAROSSA 9405+ Regionale 18207 | 06:38 Venice Mestre | 4h02 | 10:40 Siena station | 1 change | |
FRECCIAROSSA 1000 9409+ Regionale 18209 | 07:40 Venice Mestre | 3h58 | 11:38 Siena station | 1 change | |
FRECCIAROSSA 1000 9411+ Regionale 18211 | 08:38 Venice Mestre | 4h02 | 12:40 Siena station | 1 change | |
FRECCIAROSSA 1000 9413+ Regionale 18215 | 09:38 Venice Mestre | 4h02 | 13:40 Siena station | 1 change | |
FRECCIAROSSA 1000 9415+ Regionale 18217 | 10:38 Venice Mestre | 3h59 | 14:37 Siena station | 1 change | |
FRECCIAROSSA 1000 8419+ Regionale 18219 | 11:38 Venice Mestre | 4h02 | 15:40 Siena station | 1 change | |
Intercity 584+ Regionale Veloce 4043 · Regionale 18851 | 12:05 Venice Mestre | 5h10 | 17:15 Siena station | 2 changes | |
Intercity 584+ Regionale 18223 | 12:05 Venice Mestre | 5h35 | 17:40 Siena station | 1 change | |
FRECCIAROSSA 9421+ Regionale 18221 | 12:38 Venice Mestre | 4h00 | 16:38 Siena station | 1 change | |
Regionale Veloce 3977+ Intercity 597+ Regionale 18225 | 12:53 Venice Mestre | 5h45 | 18:38 Siena station | 2 changes | |
FRECCIAROSSA 1000 9425+ Regionale 18223 | 13:38 Venice Mestre | 4h02 | 17:40 Siena station | 1 change | |
Intercity 594+ Tuscany Line 4047 · Regionale 19053 | 14:34 Venice Mestre | 4h42 | 19:16 Siena station | 2 changes | |
Intercity 594+ Regionale 18227 | 14:34 Venice Mestre | 5h06 | 19:40 Siena station | 1 change | |
FRECCIAROSSA 1000 9427+ Regionale 18225 | 14:38 Venice Mestre | 4h00 | 18:38 Siena station | 1 change | |
FRECCIAROSSA 1000 9431+ Regionale 18227 | 15:38 Venice Mestre | 4h02 | 19:40 Siena station | 1 change | |
FRECCIAROSSA 1000 9433+ Regionale 18229 | 16:38 Venice Mestre | 4h01 | 20:39 Siena station | 1 change | |
Regionale Veloce 3985+ Intercity 599+ Regionale 18233 | 16:53 Venice Mestre | 5h23 | 22:16 Siena station | 2 changes | |
FRECCIAROSSA 9435+ Regionale 18233 | 17:38 Venice Mestre | 4h38 | 22:16 Siena station | 1 change | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Venice Mestre to Siena station by coach or train
Compare coach and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
23 Feb
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25 Feb
26 Feb
27 Feb
28 Feb
01 Mar
02 Mar
03 Mar
04 Mar
05 Mar
06 Mar
07 Mar
08 Mar
Why should you book Venice Mestre to Siena station trains with Omio?
Why book with Omio vs Frecciarossa?
- Compare with other providers: On Omio, you can not only buy tickets for Frecciarossa, but also compare tickets for the likes of Italo, Intercity or Regionale to find the best option for your trip from Venice Mestre to Siena station.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are bus and train to ensure you get the best deal for traveling from Venice Mestre to Siena station.
Why book with Omio over Raileurope?
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Venice Mestre to Siena station.
Journey information
Overview: Train from Venice Mestre to Siena station
Trains from Venice Mestre to Siena station run on average 17 times per day, taking around 4h 4m. Cheap train tickets for this journey start at £20 but you can travel from only £6 by coach.
The earliest train runs at 04:38, the last at 21:17. The fastest train covers the 250 km distance in 4h 0m.
Distance 250 km |
Average train duration 4h 4m |
Cheapest ticket price £20 |
Trains per day 17 |
Fastest train 4h 0m |
First train 04:38 |
Last train 21:17 |
Train companies: Frecciarossa, Italo, Intercity, Regionale from Venice Mestre to Siena station trainsFrecciarossa, Italo, Intercity, Regionale trains will get you between Venice Mestre and Siena station from £6. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Frecciarossa
Italo
Intercity
Regionale
FAQs: Venice Mestre to Siena station train
Find answers to the most common questions about traveling from Venice Mestre to Siena station by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Siena station, this guide helps you travel smarter and with confidence.

popular train stations
Important Stations and Airports in Venice Mestre and Siena station
- Mon - Sun: 05:50 - 20:30
- Provided by KiPoint and located on the ground floor.
- McDonald’s
- Chock Full O'Nuts
- Puro Gusto
- Juice Bar
- Rossosapore
- Full accessibility facilities, including toilets, ramps, wheelchairs, elevators and a mobility assistance center.
- Best Western Hotel Tritone
- The Plaza Hotel
- Hotel Villa Constanza
- Mon - Sun: 05:50 - 20:30
- Located in the main concourse.
- Bus lines: 2, 3, 10, 15, 18, 25a, 31, 31H, 32, 32H, 33H, 34H, 43, 53, 86, N1, 8AE
- Train lines: FR, FA, FB, EC, RJ, IC, EN, ICN, R, Italo
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- Parking is available near the station, open 24/7.
- Ristorante Il Vinaio
- Osteria Le Logge
- Outside the main entrance.
- Elevators, ramps.
- €1
- Hotel Italia
- NH Siena
- Hotel Minerva
- Located near the main entrance
- Located near the main entrance
- Free
- The station has a single-level layout with platforms accessible from the main hall.
- Bus: Several local and regional lines available
- Taxi: Available outside the station
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