The cheapest and fastest trains from Florence Santa Maria Novella to Palermo Centrale
Cheapest price
£81
Average price
£92
Fastest journey
12 h 47 m
Average duration
16 h 19 m
Trains per day
5
Distance
655 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Palermo Centrale is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from Florence Santa Maria Novella to Palermo Centrale will cost around £92 if you buy it on the day, but you can find cheap train tickets today for only £81.
To travel from Florence Santa Maria Novella to Palermo Centrale you need to make at least one change.
Regionale 18251+
InterCityNotte 799+
Intercity 723
ETRUSCHI LINE 18255+
Intercity 501 · Intercity 727
FRECCIAROSSA 9519+
Intercity 727
FRECCIAROSSA 9435+
InterCityNotte 1959
Regionale 18783+
Intercity 594+
InterCityNotte 1959
FRECCIAROSSA 9519+
Intercity 727
FRECCIAROSSA 9435+
InterCityNotte 1959
ETRUSCHI LINE 18255+
Intercity 501 · Intercity 727
Regionale 18783+
Intercity 594+
InterCityNotte 1959
Regionale 18251+
InterCityNotte 799+
Intercity 723Travel Information
Compare train, coach, flight and ferry for Florence Santa Maria Novella to Palermo Centrale
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Palermo Centrale among Omio's users. If you are prioritising price take the coach with prices starting from £14. For those with little time consider booking a flight which can get you there in 1h 43m. The ticket price range depends on the travel mode: a coach costs an average of £14, and a train costs an average of £62.
Distance: 655 km
Compare train with
Most popular Train | Coach | Flight | Ferry |
|---|---|---|---|
£101 Average Price | £42 Average Price Cheapest | £81 Average Price | £48 Average Price |
13h 12m Average total duration 12h 42m Onboard + 30m Additional time* | 16h 47m Average total duration 16h 17m Onboard + 30m Additional time* | 4h 43m Average total duration Fastest 1h 43m Onboard + 3h 0m Additional time* | 21h 0m Average total duration 20h 0m Onboard + 1h 0m Additional time* |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular ferry company |
Direct Options | Direct Options | Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Palermo Centrale train times
The table below shows live departures for Florence Santa Maria Novella to Palermo Centrale trains for today, Saturday 7 March. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
![]() | 23:40 Florence Santa Maria Novella | 18h48 | 18:28 Palermo Centrale | 0 changesdirect | |
Regionale 18251+ InterCityNotte 799+ Intercity 723 | 23:40 Florence Santa Maria Novella | 18h30 | 18:10 Palermo Centrale | 2 changes | |
| Sunday 8 March | |||||
ETRUSCHI LINE 18255+ Intercity 501 · Intercity 727 | 04:27 Florence Santa Maria Novella | 17h34 | 22:01 Palermo Centrale | 2 changes | |
FRECCIAROSSA 9519+ Intercity 727 | 09:14 Florence Santa Maria Novella | 12h47 | 22:01 Palermo Centrale | 1 change | |
Regionale 18783+ Intercity 594+ InterCityNotte 1959 | 17:20 Florence Santa Maria Novella | 17h35 | 10:55 Palermo Centrale | 2 changes | |
FRECCIAROSSA 9435+ InterCityNotte 1959 | 19:48 Florence Santa Maria Novella | 15h07 | 10:55 Palermo Centrale | 1 change | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Palermo Centrale by train, coach, flight or ferry
Compare train, coach, flight and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
08 Mar
09 Mar
10 Mar
11 Mar
12 Mar
13 Mar
14 Mar
Why should you book Florence Santa Maria Novella to Palermo Centrale trains with Omio?
Why book with Omio vs Intercity Notte?
- Compare with other providers: On Omio, you can not only buy tickets for Intercity Notte, but also compare tickets for the likes of Intercity, Italo, Frecciargento or Frecciarossa to find the best option for your trip from Florence Santa Maria Novella to Palermo Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Intercity Notte with all available travel options, which are train, bus, flight and ferry to ensure you get the best deal for traveling from Florence Santa Maria Novella to Palermo Centrale.
Journey information
Overview: Train from Florence Santa Maria Novella to Palermo Centrale
Trains from Florence Santa Maria Novella to Palermo Centrale run on average 6 times per day, taking around 12h 42m. Cheap train tickets for this journey start at £62 but you can travel from only £14 by coach.
The earliest train runs at 04:35, the last at 23:40. The fastest train covers the 655 km distance in 15h 9m.
Distance 655 km |
Average train duration 12h 42m |
Cheapest ticket price £62 |
Trains per day 6 |
Fastest train 15h 9m |
First train 04:35 |
Last train 23:40 |
Train companies: Intercity Notte, Intercity, Italo, Frecciargento, Frecciarossa from Florence Santa Maria Novella to Palermo Centrale trainsIntercity Notte, Intercity, Italo, Frecciargento, Frecciarossa trains will get you between Florence Santa Maria Novella and Palermo Centrale from £14. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Intercity Notte
Intercity
Italo
Frecciargento
Frecciarossa
FAQs: Florence Santa Maria Novella to Palermo Centrale train
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Palermo Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Palermo Centrale, this guide helps you travel smarter and with confidence.

popular train stations
Important Stations and Airports in Florence Santa Maria Novella and Palermo Centrale
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo



