The cheapest and fastest trains from Florence Santa Maria Novella to Palermo Centrale
Cheapest price
£98
Average price
£100
Fastest journey
14 h 6 m
Average duration
15 h 13 m
Trains per day
2
Distance
655 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Palermo Centrale is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from Florence Santa Maria Novella to Palermo Centrale will cost around £100 if you buy it on the day, but you can find cheap train tickets today for only £98.
Of the 2 trains that leave Florence Santa Maria Novella for Palermo Centrale every day 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
These direct trains cover the 655 km distance in an average of 15 h 13 m but if you time it right, some trains will get you there in just 14 h 6 m .
The slowest trains will take 16 h 20 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, coach, flight and ferry for Florence Santa Maria Novella to Palermo Centrale
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Palermo Centrale among Omio's users. If you are prioritising price take the ferry with prices starting from £34. For those with little time consider booking a flight which can get you there in 1h 43m. The ticket price range depends on the travel mode: a ferry costs an average of £34, and a flight costs an average of £28.
Distance: 655 km
Compare train with
Most popular Train | Flight | Coach | Ferry |
|---|---|---|---|
£100 Average Price | £118 Average Price | £67 Average Price | £50 Average Price Cheapest |
13h 9m Average total duration 12h 39m Onboard + 30m Additional time* | 4h 43m Average total duration Fastest 1h 43m Onboard + 3h 0m Additional time* | 16h 38m Average total duration 16h 8m Onboard + 30m Additional time* | 21h 0m Average total duration 20h 0m Onboard + 1h 0m Additional time* |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular ferry company |
Direct Options | Direct Options | Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Palermo Centrale train times
The table below shows live departures for Florence Santa Maria Novella to Palermo Centrale trains for today, Saturday 6 December. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
![]() | 16:22 Florence Santa Maria Novella | 17h35 | 09:57 Palermo Centrale | 0 changesdirect | |
![]() | 21:07 Florence Santa Maria Novella | 19h55 | 17:02 Palermo Centrale | 0 changesdirect | |
| Sunday 7 December | |||||
![]() | 04:35 Florence Santa Maria Novella | 16h20 | 20:55 Palermo Centrale | 0 changesdirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Palermo Centrale by train, coach, flight or ferry
Compare train, coach, flight and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
07 Dec
08 Dec
09 Dec
10 Dec
11 Dec
12 Dec
13 Dec
Journey information
Overview: Train from Florence Santa Maria Novella to Palermo Centrale
Trains from Florence Santa Maria Novella to Palermo Centrale run on average 6 times per day, taking around 12h 39m. Cheap train tickets for this journey start at £57 but you can travel from only £28 by flight.
The earliest train runs at 03:45, the last at 18:48. The fastest train covers the 655 km distance in 13h 2m.
Distance 655 km |
Average train duration 12h 39m |
Cheapest ticket price £57 |
Trains per day 6 |
Fastest train 13h 2m |
First train 03:45 |
Last train 18:48 |
Train companies: Intercity Notte, Intercity, Italo, Frecciargento, Frecciarossa from Florence Santa Maria Novella to Palermo Centrale trainsIntercity Notte, Intercity, Italo, Frecciargento, Frecciarossa trains will get you between Florence Santa Maria Novella and Palermo Centrale from £28. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Intercity Notte
Intercity
Italo
Frecciargento
Frecciarossa
FAQs: Florence Santa Maria Novella to Palermo Centrale train
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Palermo Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Palermo Centrale, this guide helps you travel smarter and with confidence.

popular train stations
Important Stations and Airports in Florence Santa Maria Novella and Palermo Centrale
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo




