Travel Information
Compare coach and flight for Siena to Brussels
Omio recommends booking the coach as it is the most popular option from Siena to Brussels among Omio's users. If you are prioritising price, take the flight, with an average ticket price of £51 For those with little time, consider booking a flight, which has an average total journey time of 3h 49m. Average ticket prices depend on the travel mode: a flight costs an average of £51, while a coach costs an average of £77.
Distance: 989 km
Compare bus with
Most popular Coach | Flight | Driving |
|---|---|---|
£77 Average Price | £51 Average Price Cheapest | £17 Average Price (fuel + tolls) |
21h 12m Average total duration 20h 42m Onboard + 30m Additional time* | 3h 49m Average total duration Fastest 1h 49m Onboard + 2h 0m Additional time* | 13h 23m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Siena to Brussels:
A flight is £26 less than a coach for this route with tickets for a coach from Siena to Brussels costing on average £77.
Other travel options to Brussels take longer:
Coach takes on average 21h 12m.
Tickets start at around £77 compared to roughly £17 in fuel and tolls — a saving of about £-59.29. The journey takes 20h 42m versus 13h 23m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Siena to Brussels
How to get to Brussels from Siena by train, bus, flight or ferry.
Our recommendation
The best way to travel from Siena to Brussels is by taking a coach because it’s the best combination of price and speed.
22:4526h20Siena1:05Brussels£871One-way0 changes
Cheapest
22:4526h20Siena1:05Brussels£871One-way0 changes
Fastest
22:4526h20Siena1:05Brussels£871One-way0 changes
Other options
12:5128h09Siena17:00Brussels£1021One-way0 changes
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, coaches, flights and ferries
Compare coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Siena to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Siena to Brussels.

This is compared to other travel options from Siena to Brussels:
A flight is £26 less than a coach for this route with tickets for a coach from Siena to Brussels costing on average £77.
Other travel options to Brussels take longer:
Coach takes on average 21h 12m.
- Around 22 flights per day.
- Around 5 coaches per day.
However, we recommend checking specific travel dates for your route between Siena and Brussels as scheduled services by coach and flight can vary by season or day of the week.
- Flights mostly depart from Florence Peretola Airport and arrive in Brussels Airport.
- Coaches mostly depart from Siena, Stazione FS (Piazzale Carlo Rosselli) and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with FlixBus to go to Brussels by coach.
- Travel with Malta Air to go to Brussels by flight.
- 2 direct flights per day with Malta Air.
Travelling from Siena to Brussels: related information
Here are some other resources that might have the information you need

