Travel Information
Compare train, coach and flight for Prague to Mainz
Omio recommends booking the train as it is the most popular option from Prague to Mainz among Omio's users. If you are prioritising price take the coach with prices starting from £24. For those with little time consider booking a flight which can get you there in 1h 15m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a coach costs an average of £24, and a flight costs an average of £64.
Distance: 439 km
Compare train with
Most popular Train | Coach | Flight |
|---|---|---|
£101 Average Price | £32 Average Price Cheapest | £132 Average Price |
8h 2m Average total duration 7h 32m Onboard + 30m Additional time* | 7h 32m Average total duration 7h 2m Onboard + 30m Additional time* | 4h 15m Average total duration Fastest 1h 15m Onboard + 3h 0m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Prague to Mainz
How to get to Mainz from Prague by train, bus, flight or ferry.
Our recommendation
The best way to travel from Prague to Mainz is by taking a coach because it’s the best combination of price and speed.
FlixBus4:108h05Praha, Na Knížecí12:15Mainz, Binger Schlag (Kurzzeitparkplatz)£291One-way0 changes
Cheapest
FlixBus4:108h05Praha, Na Knížecí12:15Mainz, Binger Schlag (Kurzzeitparkplatz)£291One-way0 changes
Fastest
DE440817:001h00Prague Vaclav Havel Airport18:00Frankfurt am Main Airport£1201One-way0 changes
Other options
R 688 · Os 28009 · S1 · ICE 259412:479h02Prague hlavní nádraží21:49Mainz Hbf£491One-way4 changes
EX 358 · 3568 · ICE 624 · S89:358h20Prague hlavní nádraží17:55Mainz Hbf£541One-way3 changes
R 692 · Os 28005 · S1 · ICE 15688:479h02Prague hlavní nádraží17:49Mainz Hbf£601One-way4 changes
FlixBus3:508h25Prague, Central Train Station12:15Mainz, Binger Schlag (Kurzzeitparkplatz)£291One-way0 changes
(Prague -> Amsterdam)23:006h55Praha, ÚAN Florenc5:55Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)£361One-way0 changes
FlixBus · FlixBus7:5511h35Praha, Na Knížecí19:30Mainz, Binger Schlag (Kurzzeitparkplatz)£371One-way1 change
LH139511:551h10Prague Vaclav Havel Airport13:05Frankfurt am Main Airport£861One-way0 changes
LH139714:401h10Prague Vaclav Havel Airport15:50Frankfurt am Main Airport£861One-way0 changes
LH140118:401h10Prague Vaclav Havel Airport19:50Frankfurt am Main Airport£861One-way0 changes
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, coaches, flights and ferries
Compare train, coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Prague to Mainz
Travel to Mainz easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Mainz.

This is compared to other travel options from Prague to Mainz:
A coach is £69 less than a train for this route with tickets for a train from Prague to Mainz costing on average £101.
A coach is £100 less than a flight for this route with tickets for a flight from Prague to Mainz costing on average £132.
Other travel options to Mainz take longer:
Coach takes on average 7h 2m.
Train takes on average 7h 32m.
- Around 74 flights per day.
- Around 7 trains per day.
- Around 6 coaches per day.
However, we recommend checking specific travel dates for your route between Prague and Mainz as scheduled services by train, coach and flight can vary by season or day of the week.
- Flights mostly depart from Prague Vaclav Havel Airport and arrive in Frankfurt am Main Airport.
- Trains mostly depart from Prague hlavní nádraží and arrive in Mainz Hbf.
- Coaches mostly depart from Praha, ÚAN Florenc and arrive in Mainz, Binger Schlag (Kurzzeitparkplatz).
- Travel with Lufthansa, Air Dolomiti to go to Mainz by flight.
- Travel with Deutsche Bahn, České dráhy, ÖBB | Euro City (EC), České dráhy (ČD), ÖBB | Railjet to go to Mainz by train.
- Travel with FlixBus, BlaBlaCar to go to Mainz by coach.
- 9 direct flights per day with Lufthansa, Air Dolomiti.
- 3 direct coaches per day with FlixBus, BlaBlaCar.
Travelling from Prague to Mainz: related information
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