Travel Information
Compare train, coach and flight for Mainz to Lyon
Omio recommends booking the train as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price, take the train, with an average ticket price of £20 For those with little time, consider booking a flight, which has an average total journey time of 4h 41m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a train costs an average of £20, while a flight costs an average of £383.
Distance: 536 km
Compare train with
Most popular Train | Flight | Coach | Driving |
|---|---|---|---|
£20 Average Price Cheapest | £383 Average Price | £54 Average Price | £131 Average Price (fuel + tolls) |
7h 5m Average total duration 6h 35m Onboard + 30m Additional time* | 4h 41m Average total duration Fastest 2h 41m Onboard + 2h 0m Additional time* | 13h 55m Average total duration 13h 25m Onboard + 30m Additional time* | 6h 50m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 1.6 - 3.2kg CO2 emissions | 0.5 - 1.3kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Mainz to Lyon
Compare the available ways to get from Mainz to Lyon, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Mainz to Lyon:
A train is £35 less than a coach for this route with tickets for a coach from Mainz to Lyon costing on average £54.
A train is £364 less than a flight for this route with tickets for a flight from Mainz to Lyon costing on average £383.
Other travel options to Lyon take longer:
Train takes on average 7h 5m.
Coach takes on average 13h 55m.
The journey is about 15m faster (6h 35m by train vs 6h 50m by car) and roughly £112 cheaper once you factor in fuel and tolls (£20 vs £131). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Travel optionsfrom Mainz to Lyon
How to get to Lyon from Mainz by train, bus, flight or ferry.
Our recommendation
The best way to travel from Mainz to Lyon is by taking a coach because it’s the best combination of price and speed.
FlixBus · FlixBus16:2020h20Mainz, Binger Schlag (Kurzzeitparkplatz)12:40Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£621One-way1 change
Cheapest
FlixBus · FlixBus16:2020h20Mainz, Binger Schlag (Kurzzeitparkplatz)12:40Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£621One-way1 change
Fastest
LH4105+
LH22488:303h50Cologne Bonn Airport12:20Lyon Saint Exupery Airport£5951One-way1 change
Other options
S6 · ICE 9590+
55378:579h02Mainz Römisches Theater station17:59Lyon Part Dieu£1521One-way2 changes
S6 · ICE 9590+
121778:579h02Mainz Römisches Theater station17:59Lyon Part Dieu£1521One-way2 changes
S5 · ICE 9590+
121778:269h33Mainz Römisches Theater station17:59Lyon Part Dieu£1521One-way2 changes
FlixBus · FlixBus · FlixBus10:3017h50Mainz, Binger Schlag (Kurzzeitparkplatz)4:20Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£801One-way2 changes
FlixBus · FlixBus22:4014h15Mainz, Binger Schlag (Kurzzeitparkplatz)12:55Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£911One-way1 change
FlixBus · FlixBus · FlixBus8:2014h55Mainz, Binger Schlag (Kurzzeitparkplatz)23:15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£1061One-way2 changes
ICE 23+
LH10787:4010h30Mainz Hbf18:10Lyon Saint Exupery Airport£2781One-way1 change
ICE 23+
KL1818 · KL14357:4015h10Mainz Hbf22:50Lyon Saint Exupery Airport£3471One-way2 changes
TK1676 · TK180719:1514h00Cologne Bonn Airport9:15Lyon Saint Exupery Airport£3601One-way1 change
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, coaches, flights and ferries
Compare train, coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Mainz to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Lyon.

This is compared to other travel options from Mainz to Lyon:
A train is £35 less than a coach for this route with tickets for a coach from Mainz to Lyon costing on average £54.
A train is £364 less than a flight for this route with tickets for a flight from Mainz to Lyon costing on average £383.
Other travel options to Lyon take longer:
Train takes on average 7h 5m.
Coach takes on average 13h 55m.
- Around 30 flights per day.
- Around 15 trains per day.
- Around 4 coaches per day.
However, we recommend checking specific travel dates for your route between Mainz and Lyon as scheduled services by train, coach and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Lyon Saint Exupery Airport.
- Coaches mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
- Trains mostly depart from Mainz Römisches Theater station and arrive in Lyon Part Dieu.
- Travel with TGV, SNCF | TGV INOUI, SNCF | Intercités de nuit to go to Lyon by train.
- Travel with FlixBus to go to Lyon by coach.
- Travel with Lufthansa, BA Euroflyer, Lufthansa Cityline, KLM Cityhopper, CitizenPlane, Brussels Airlines, Lufthansa City Airlines, Air France, KLM, Air Dolomiti, Austrian Airlines, Air Baltic, Turkish Airlines, Helvetic Airways, Lot Polish Airlines, British Airways to go to Lyon by flight.
- 4 direct flights per day with Lufthansa, Air Dolomiti.
Travelling from Mainz to Lyon: related information
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