Travel Information
Compare train, coach and flight for Mainz to Lyon
Omio recommends booking the flight as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price take the coach with prices starting from £30. For those with little time consider booking a flight which can get you there in 1h 18m. In case you are seeking to minimise your carbon footprint the coach is your best bet as it emits only 0.5 - 1.3kg. The ticket price range depends on the travel mode: a coach costs an average of £30, and a flight costs an average of £120.
Distance: 536 km
Compare flight with
Most popular Flight | Coach |
|---|---|
£235 Average Price | £47 Average Price Cheapest |
4h 18m Average total duration Fastest 1h 18m Onboard + 3h 0m Additional time* | 10h 40m Average total duration 10h 10m Onboard + 30m Additional time* |
1.6 - 3.2kg CO2 emissions | 0.5 - 1.3kg CO2 emissions Lowest |
![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Mainz to Lyon
How to get to Lyon from Mainz by train, bus, flight or ferry.
Our recommendation
The best way to travel from Mainz to Lyon is by taking a coach because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus22:3014h20Mainz, Binger Schlag (Kurzzeitparkplatz)12:50Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£511One-way2 changes
Cheapest
FlixBus · FlixBus · FlixBus22:3014h20Mainz, Binger Schlag (Kurzzeitparkplatz)12:50Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£511One-way2 changes
Fastest
LH107612:201h20Frankfurt am Main Airport13:40Lyon Saint Exupery Airport£3401One-way0 changes
Other options
S6 · ICE 9590+
121778:579h02Mainz Römisches Theater station17:59Lyon Part Dieu£1331One-way2 changes
S6 · ICE 9590+
55378:579h02Mainz Römisches Theater station17:59Lyon Part Dieu£1331One-way2 changes
S5 · ICE 9590+
55378:269h33Mainz Römisches Theater station17:59Lyon Part Dieu£1331One-way2 changes
FlixBus · FlixBus22:4016h05Mainz, Binger Schlag (Kurzzeitparkplatz)14:45Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£541One-way1 change
FlixBus · FlixBus · FlixBus10:3018h05Mainz, Binger Schlag (Kurzzeitparkplatz)4:35Lyon£641One-way2 changes
FlixBus · FlixBus · FlixBus10:3018h20Mainz, Binger Schlag (Kurzzeitparkplatz)4:50Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)£641One-way2 changes
AF1219 · AF737015:106h50Frankfurt am Main Airport22:00Lyon Saint Exupery Airport£2031One-way1 change
AF1519 · AF73689:458h05Frankfurt am Main Airport17:50Lyon Saint Exupery Airport£2031One-way1 change
ICE 23+
AF1219 · AF73707:4014h20Mainz Hbf22:00Lyon Saint Exupery Airport£2091One-way2 changes
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, coaches, flights and ferries
Compare train, coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Mainz to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Lyon.

This is compared to other travel options from Mainz to Lyon:
A coach is £189 less than a flight for this route with tickets for a flight from Mainz to Lyon costing on average £235.
Other travel options to Lyon take longer:
Train takes on average 6h 2m.
Coach takes on average 10h 10m.
- Around 21 flights per day.
- Around 4 coaches per day.
- Around 3 trains per day.
However, we recommend checking specific travel dates for your route between Mainz and Lyon as scheduled services by train, coach and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Lyon Saint Exupery Airport.
- Coaches mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Lyon, Perrache Bus Station.
- Trains mostly depart from Frankfurt (Main) Hbf and arrive in Lyon Part Dieu.
- Travel with TGV, SNCF | TGV INOUI, vlexx to go to Lyon by train.
- Travel with FlixBus, ORN Omnibusverkehr Rhein-Nahe GmbH to go to Lyon by coach.
- Travel with Lufthansa to go to Lyon by flight.
- 1 direct trains per day with SNCF | TGV INOUI.
- 4 direct flights per day with Lufthansa.
Travelling from Mainz to Lyon: related information
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