
Travel optionsfrom Madrid to Santiago
How to get to Santiago from Madrid by train, bus, flight or ferry.
Our recommendation
The best way to travel from Madrid to Santiago is by taking a flight because it’s the best combination of price and speed.
IB658623:35 13h20 Madrid Barajas Airport 8:55 Santiago £891 1 One-way 0 changes
Cheapest
IB658623:35 13h20 Madrid Barajas Airport 8:55 Santiago £891 1 One-way 0 changes
Fastest
IB658623:35 13h20 Madrid Barajas Airport 8:55 Santiago £891 1 One-way 0 changes
Other options
IB665111:05 13h40 Madrid Barajas Airport 20:45 Santiago £891 1 One-way 0 changes
LA70523:35 13h20 Madrid Barajas Airport 8:55 Santiago £956 1 One-way 0 changes
LA70711:05 13h40 Madrid Barajas Airport 20:45 Santiago £956 1 One-way 0 changes
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, coaches, flights and ferries
Compare flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Best day trips from Santiago by bus
The most popular day trips by bus from Santiago are Valparaíso, Viña del Mar, Rancagua and Melipilla. Find out what you can do in these day trip destinations and how to book your bus from Santiago on Omio.


Day trip from Santiago to Viña del Mar by bus

Day trip from Santiago to Rancagua by bus

Day trip from Santiago to Melipilla by bus
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FAQs: Madrid to Santiago
Travel to Santiago easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Madrid to Santiago.

- Around 84 flights per day.
However, we recommend checking specific travel dates for your route between Madrid and Santiago as scheduled services by flight can vary by season or day of the week.
- Flights mostly depart from Madrid Barajas Airport and arrive in Santiago.
- Travel with Iberia, Air France, Avianca, Latam Airlines, British Airways, KLM, Lufthansa, American Airlines, Swiss, Air Europa, Aerolineas Argentinas, CitizenPlane to go to Santiago by flight.
- 7 direct flights per day with Iberia, Latam Airlines, CitizenPlane.
Travelling from Madrid to Santiago: related information
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