Travel Information from Detroit, MI to St. Louis, MO
| 453 miles | |
| Coach, train or flight | |
| £48 - £91 | |
| Coach • £48 • 15 h | |
| Flight • £91 • 4 h 33 min | |
| Greyhound, American Airlines or Amtrak |
Take a coach, train or flight to travel 453 miles from Detroit, MI to St. Louis, MO. The most popular travel providers which serve this trip are Greyhound, American Airlines or Amtrak among others. Travellers can even take a direct coach, flight or train from Detroit, MI to St. Louis, MO.
Travel optionsfrom Detroit, MI to St. Louis, MO
How to get to St. Louis, MO from Detroit, MI by train, bus, flight or ferry.
Our recommendation
The best way to travel from Detroit, MI to St. Louis, MO is by taking a coach because it’s the best combination of price and speed.
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UA3425 · UA4613Other options
351 Wolverine · 21 Texas Eagle
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FlixBus
AA6289 · AA5003
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AA4595
UA5381 · UA5873Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Detroit, MI to St. Louis, MO
Travel to St. Louis, MO easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Detroit, MI to St. Louis, MO.

There are 3 travel options to St. Louis, MO from Detroit, MI. You can take a coach, train or flight.
The cheapest way to go to St. Louis, MO from Detroit, MI is by taking a coach, which costs on average £48.
This is compared to other ways of getting from Detroit, MI to St. Louis, MO:
Taking a coach costs £44 less than taking a flight, which costs on average £91 for the same trip.
Taking a coach costs £20 less than taking a train, which costs on average £68 for the same trip.
The fastest way from Detroit, MI to St. Louis, MO is by flight with an average journey time of 4 h 33 min.
There are alternative travel options to St. Louis, MO that take longer:
Getting to St. Louis, MO by coach takes 15 h on average.
Getting to St. Louis, MO by train takes 13 h 41 min on average.
The Detroit, MI to St. Louis, MO distance is approximately 453 miles.
The average frequency per day from Detroit, MI to St. Louis, MO is:
- Around 3 coaches per day.
- Around 16 flights per day.
- 2 trains a day.
However, we recommend checking specific travel dates for your route between Detroit, MI and St. Louis, MO as scheduled services by coach, train or flight can vary by season or day of the week.
These are the most popular departure and arrival points when travelling from Detroit, MI to St. Louis, MO:
Omio works with many trusted partners that can help you travel the best way from Detroit, MI to St. Louis, MO:
- You can go to St. Louis, MO from Detroit, MI by coach with Greyhound. You'll see cheap coach tickets for £58 with Greyhound from Detroit, MI to St. Louis, MO on Omio.
- You can take a flight from Detroit, MI to St. Louis, MO with American Airlines. Cheap tickets can be found for £91 with American Airlines from Detroit, MI to St. Louis, MO.
- You can travel by train from Detroit, MI to St. Louis, MO with Amtrak, and you can find Amtrak Detroit, MI to St. Louis, MO tickets for £68 on Omio.
Yes, there are direct routes from Detroit, MI to St. Louis, MO with the following travel companies:
- You can book a direct coach with.
- You can travel directly by plane with.
- You can book a direct train with.
Direct services to St. Louis, MO tend to save you time and add more convenience as you won't need to transfer at another stop in between, so it's worth paying attention to before booking tickets for your trip.
Travelling from Detroit, MI to St. Louis, MO: related information
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