La Serena to Santiago bus with FlixBus

Fri 15 May
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FlixBus
Sky Airline
Condor Bus
Turbus
Pullman Bus
2,000+ travel companies
FlixBus
Sky Airline
Condor Bus
Turbus
Pullman Bus
2,000+ travel companies
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The cheapest and fastest coaches from La Serena to Santiago

Showing times and prices for 15 May

Cheapest price

£13

Average price

£17

Fastest journey

5 h 40 m

Average duration

6 h 4 m

Buses per day

7

Distance

399 km

Cheap tickets

The best way to find a cheap coach ticket from La Serena to Santiago is to book your journey as far in advance as possible and to avoid travelling at rush hour.

The average ticket from La Serena to Santiago will cost around £17 if you buy it on the day, but you can find cheap coach tickets today for only £13.

Fast coaches

Of the 7 buses that leave La Serena for Santiago every day 7 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

These direct buses cover the 399 km distance in an average of 6 h 4 m but if you time it right, some buses will get you there in just 5 h 40 m .

The slowest buses will take 6 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • FlixBus
    19:155h40
    La Serena
    0:55Santiago
    £131One-way
    0 changes
  • FlixBus
    14:507h15
    La Serena
    22:05Santiago
    £151One-way
    0 changes
  • FlixBus
    15:407h15
    La Serena
    22:55Santiago
    £161One-way
    0 changes
  • FlixBus
    11:006h30
    La Serena
    17:30Santiago
    £161One-way
    0 changes
  • FlixBus
    21:005h59
    La Serena
    2:59Santiago
    £191One-way
    0 changes

Travel Information

Compare coach and flight for La Serena to Santiago

Omio recommends booking the coach as it is the most popular option from La Serena to Santiago among Omio's users. If you are prioritising price take the coach with prices starting from £9. For those with little time consider booking a flight which can get you there in 2h 15m. The ticket price range depends on the travel mode: a coach costs an average of £9, and a flight costs an average of £23.

Distance: 399 km

Compare bus with

Most popular
Coach
Flight

£16

Average Price

Cheapest

£48

Average Price

4h 4m

Average total duration

3h 34m

Onboard

+

30m

Additional time*

5h 15m

Average total duration

Fastest

2h 15m

Onboard

+

3h 0m

Additional time*

FlixBus

Most popular bus company

jetsmart

Most popular airline

Direct Options

Direct Options

Live departures

La Serena to Santiago bus times

The table below shows live departures for La Serena to Santiago coaches for tomorrow, Friday 15 May. You can also manually refresh the results below to see updated coach journeys.

Last updated at
ProviderDepartsDurationArrivesChanges
Tickets
FlixBus11:00 La Serena
6h30
17:30 Santiago0 changesdirect
FlixBus14:50 La Serena
7h15
22:05 Santiago0 changesdirect
FlixBus15:40 La Serena
7h15
22:55 Santiago0 changesdirect
FlixBus18:15 La Serena
5h40
23:55 Santiago0 changesdirect
FlixBus19:15 La Serena
5h40
0:55 Santiago0 changesdirect
FlixBus20:15 La Serena
6h30
2:45 Santiago0 changesdirect
FlixBus21:00 La Serena
5h59
2:59 Santiago0 changesdirect

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets La Serena to Santiago by coach or flight

Compare coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Fri
15 May
Sat
16 May
Sun
17 May
Mon
18 May
Tue
19 May
Wed
20 May
Thu
21 May

Why should you book La Serena to Santiago coaches with Omio?

FlixBus as well as Sky Airline, Condor Bus, Turbus, Pullman Bus and more offer coaches services from La Serena to Santiago.
Omio is an official ticket reseller for all your travel options from La Serena to Santiago.

Why book with Omio vs FlixBus?

  • Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Sky Airline, Condor Bus, Turbus or Pullman Bus to find the best option for your trip from La Serena to Santiago.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from La Serena to Santiago.

Why book with Omio over Wanderu or Trainline?

  • Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from La Serena to Santiago.

Journey information

Overview: Bus from La Serena to Santiago

ChileChile
ChileChile
Icon of bus

Buses from La Serena to Santiago run on average 25 times per day, taking around 3h 34m. Cheap bus tickets for this journey start at £9 if you book in advance.

There are 25 coaches per day. The earliest coach runs at 00:01, the last at 23:50. The fastest coach covers the 399 km distance in 5h 40m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
399 km
Average bus duration
3h 34m
Cheapest ticket price
£9
Buses per day
25
Direct buses
25
Fastest bus
5h 40m
First bus
0:01
Last bus
23:50
Cheapest Month
Sept
Cheapest Day
Wed
High Season
Jan - Mar
Low Season
Apr - Jun
Busiest Day
Sun
Least Busy Day
Thu
Best time to book
4 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: FlixBus, Sky Airline, Condor Bus, Turbus, Pullman Bus, Pluss Chile, Flixbus Chile from La Serena to SantiagoYou can travel by bus between La Serena to Santiago with FlixBus, Sky Airline, Condor Bus, Turbus, Pullman Bus, Pluss Chile, Flixbus Chile for as low as £9. When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
5h 40m
Cheapest Price
£9
FlixBus frequency
25 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Learn more about FlixBus

Sky Airline

Luggage & cancellation policy
Average Duration
58m
Cheapest Price
£30
Luggage included
1 carry-on bag (45x35x25cm) max 10kg
Additional luggage
23kg checked baggage available for purchase
Cancellation Policy
Free cancellation within 24 hours of booking if flight is more than 7 days away. After that, fees apply based on fare type.
Pregnant on board
Up to 36 weeks for single pregnancies, 32 weeks for multiple pregnancies. Medical certificate required after 28 weeks
Unaccompagned minor
Children aged 5-17 can travel unaccompanied with service fee. Must be requested 48 hours before flight
Amenities on board the bus
Wifi
USB plugs
Accessibility
Assistance available for passengers with reduced mobility, must be requested 48 hours before flight
Pets
Dogs and cats allowed in cabin and cargo hold, must be in approved carrier

Condor Bus

Luggage & cancellation policy
Average Duration
6h 30m
Cheapest Price
£18
Condor Bus frequency
1 a day

Turbus

Luggage & cancellation policy
Average Duration
5h 40m
Cheapest Price
£25
Turbus frequency
8 a day

Pullman Bus

Luggage & cancellation policy
Average Duration
6h 10m
Cheapest Price
£23
Pullman Bus frequency
6 a day

Pluss Chile

Luggage & cancellation policy
Average Duration
6h 30m
Cheapest Price
£16
Pluss Chile frequency
4 a day

Flixbus Chile

Luggage & cancellation policy
Average Duration
6h 5m
Cheapest Price
£7
Flixbus Chile frequency
5 a day

FAQs: La Serena to Santiago coach

Find answers to the most common questions about traveling from La Serena to Santiago by coach. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest coach, the cheapest option, or tips for making the most of your visit at Santiago, this guide helps you travel smarter and with confidence.

FAQs
Cheap coach tickets from La Serena to Santiago can start from as little as £9 when you book in advance. The average coach ticket price for La Serena to Santiago is £16; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by coach from La Serena to Santiago is 5h 40m to travel the 399 km long route. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest coach from La Serena to Santiago leaves at 0:01. Plan your trip with the Journey Planner from Omio.
The latest coach from La Serena to Santiago leaves at 23:50.
Yes, there are 25 direct coaches a day from La Serena to Santiago with FlixBus, Sky Airline, Condor Bus, Turbus, Pullman Bus, Pluss Chile, Flixbus Chile. Schedules can vary on holidays or weekends with fewer direct coaches.
When taking a coach from La Serena to Santiago, you can count on FlixBus, Sky Airline, Condor Bus, Turbus, Pullman Bus, Pluss Chile, Flixbus Chile for the best way to get you to Santiago. You can also check all possible coach companies who offer a service between La Serena and Santiago and compare the amenities they offer before buying a coach ticket.
A trip to Santiago from La Serena is worth doing but not as a day trip with a journey time of 5h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a coach from La Serena to Santiago is September.
It's helpful to compare your options as there are 2 ways to travel between La Serena and Santiago including taking a coach and flight.
Yes, the following accessibility options are available when taking the coach from La Serena to Santiago:
  • Sky Airline
    • Assistance available for passengers with reduced mobility, must be requested 48 hours before flight
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the coach from La Serena to Santiago for coach company FlixBus.
Whether you can cancel your coach ticket from La Serena to Santiago depends on the coach companies:
  • Sky Airline
    • Free cancellation within 24 hours of booking if flight is more than 7 days away. After that, fees apply based on fare type.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the coach with coach company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the coach from La Serena to Santiago.
Yes, the following luggage options are included when booking a coach ticket from La Serena to Santiago:
  • Sky Airline
    • 1 carry-on bag (45x35x25cm) max 10kg
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a coach ticket from La Serena to Santiago:
  • Sky Airline
    • 23kg checked baggage available for purchase
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the coach from La Serena to Santiago. The following conditions apply:
  • Sky Airline
    • Dogs and cats allowed in cabin and cargo hold, must be in approved carrier
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the coach from La Serena to Santiago with the following coach company: FlixBus
Yes, there are USB plugs on board the coach from La Serena to Santiago with the following coach company: FlixBus, Sky Airline.
Yes, there is Wifi on board the coach from La Serena to Santiago with the following coach company: FlixBus, Sky Airline.

popular bus stations

Important Stations and Airports in La Serena and Santiago

La Serena
Santiago
The major coach station for departures in La Serena is La Serena, Terminal de buses. Find all the information you need to know about services, amenities and connections at La Serena, Terminal de buses for your trip from La Serena to Santiago.
La Serena, Terminal de buses
information
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