- Must visit
Museo Nacional de Bellas Artes
Leading museum for Chilean and international art in a beaux-arts building beside Parque Forestal. Strong permanent collection and temporary shows.
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The cheapest and fastest coaches from La Serena to Santiago
Showing times, prices and bookable tickets for 29 Sept
Cheapest price on 29 Sept
£13
Average ticket price on 29 Sept
£17
Fastest journey on 29 Sept
5 h 40 m
Average journey duration on 29 Sept
5 h 49 m
Buses on 29 Sept
7
Distance
399 km
Cheap tickets
The best way to find a cheap coach ticket from La Serena to Santiago is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from La Serena to Santiago will cost around £17 if you buy it on the day, but you can find cheap coach tickets today for only £13.
Fast coaches
On Tue 29 Sept, we found 7 buses from La Serena to Santiago, including 7 direct services.
These direct buses cover the 399 km distance in an average of 5 h 49 m but if you time it right, some buses will get you there in just 5 h 40 m .
The slowest buses will take 6 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
18:155h40La Serena23:55Santiago£131One-way0 changes- 21:005h59La Serena2:59Santiago£141One-way0 changes
- 19:155h40La Serena0:55Santiago£141One-way0 changes
- 13:005h40La Serena18:40Santiago£181One-way0 changes
- 14:006h05La Serena20:05Santiago£181One-way0 changes
- 13:005h40La Serena18:40Santiago£181One-way0 changes
- 18:155h40La Serena23:55Santiago£131One-way0 changes
- 19:155h40La Serena0:55Santiago£141One-way0 changes
- 21:005h59La Serena2:59Santiago£141One-way0 changes
- 14:006h05La Serena20:05Santiago£181One-way0 changes
Live departures
La Serena to Santiago bus times
The table below shows live departures for La Serena to Santiago coaches for today, Monday 28 September. You can also manually refresh the results below to see updated coach journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
| FlixBus | 4:20 La Serena, Terminal de buses | 6h00 | 10:20 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 6:00 La Serena, Terminal de buses | 6h05 | 12:05 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 6:00 La Serena, Terminal de buses | 5h40 | 11:40 Santiago, Los Libertadores | 0 changesdirect | |
| FlixBus | 8:00 La Serena, Terminal de buses | 6h30 | 14:30 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 10:00 La Serena, Terminal de buses | 5h40 | 15:40 Santiago, Los Libertadores | 0 changesdirect | |
| FlixBus | 10:00 La Serena, Terminal de buses | 6h05 | 16:05 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 10:10 La Serena, Terminal de buses | 7h15 | 17:25 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 11:40 La Serena, Terminal de buses | 7h15 | 18:55 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 13:55 La Serena, Terminal de buses | 5h40 | 19:35 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 14:00 La Serena, Terminal de buses | 6h50 | 20:50 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 14:00 La Serena, Terminal de buses | 6h25 | 20:25 Santiago, Los Libertadores | 0 changesdirect | |
| FlixBus | 15:55 La Serena, Terminal de buses | 5h40 | 21:35 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 18:00 La Serena, Terminal de buses | 5h59 | 23:59 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| FlixBus | 23:30 La Serena, Terminal de buses | 6h25 | 5:55 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
| Tuesday 29 September | |||||
| 2:30 La Serena | 6h25 | 8:55 Santiago | 0 changesdirect | |
| FlixBus | 23:50 La Serena, Terminal de buses | 6h00 | 5:50 Santiago, Terminal de Buses San Borja | 0 changesdirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets La Serena to Santiago by coach or flight
Compare coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book La Serena to Santiago coaches with Omio?
FlixBus operates all coaches services from La Serena to Santiago.
Omio is an official ticket reseller for all your travel options from La Serena to Santiago.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from La Serena to Santiago.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from La Serena to Santiago.
Journey information
Overview: Bus from La Serena to Santiago
ChileChile
Buses from La Serena to Santiago run on average 23 times per day, taking around 6h 10m. Cheap bus tickets for this journey start at £9 if you book in advance.
There are 23 coaches per day. The earliest coach runs at 00:01, the last at 23:50. The fastest coach covers the 399 km distance in 5h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 399 km |
Average bus duration 6h 10m |
Cheapest ticket price £9 |
Buses per day 23 |
Direct buses 23 |
Fastest bus 5h 40m |
First bus 0:01 |
Last bus 23:50 |
Cheapest Month Sept |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Busiest Day Sun |
Least Busy Day Thu |
Best time to book 1 day |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus from La Serena to SantiagoYou can travel by bus between La Serena to Santiago with FlixBus for as low as £9. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
5h 40m
Cheapest FlixBus Price
£9
FlixBus frequency
23 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Santiago
Things to do in Santiago
Discover the best of Santiago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santiago trip today.
- Must visit
Museo Chileno de Arte Precolombino
Museum focused on pre-Columbian cultures of the Americas. It is prized for thoughtful displays, textiles, ceramics and Indigenous history.
- Recommended
Museo de Arte Contemporáneo
Contemporary art museum with rotating exhibitions in an atmospheric historic building near Bellas Artes and Parque Forestal.
- Must visit
Cerro San Cristóbal
Large urban hill park with cable car, funicular, zoo access and sweeping views. A key Santiago outing for nature and panoramas.
- Must visit
Barrio Lastarria
Walkable district with restored architecture, galleries, bookshops and plazas. Popular for culture, design and a more local central atmosphere.
- Must visit
Plaza de Armas
Main historic square surrounded by major civic and religious buildings. It is the natural starting point for exploring old Santiago.
Empanada de pino
Beef, onions, raisins, olives and egg baked in pastry. A classic Chilean empanada, especially popular for fiestas patrias and family gatherings.
- Gluten-free
Cazuela
A hearty stew of beef, maize, pumpkin, potatoes and green beans. It is a traditional winter dish with deep rural and home-cooking roots.
- Gluten-free
Porotos granados
Slow-cooked beans with pumpkin, maize and often sausage or pork. A beloved, filling Chilean home dish eaten widely in colder months.
Fuente Mardoqueo
Busy traditional fuente de soda famed for oversized sandwiches, completos and quick casual dining in central Santiago.
Galindo
Traditional Chilean venue in Barrio Bellavista serving grilled meats, seafood and local specialities with live folk music on some evenings.
Confitería Torres
Historic central Santiago restaurant known for classic Chilean dishes, seafood and old-school atmosphere with attentive formal service.
Chilean peso ($)
Moderate for South America: hotels in central areas are mid-priced, meals are reasonable, and Metro fares are low, though upscale districts and fine dining cost noticeably more.
Average meal costs
- Budget
- $6,000-$10,000 for fast food or casual meals.
- Mid-range
- $12,000-$22,000 per person for a restaurant meal.
- Fine dining
- $35,000+ per person for upscale restaurants.
- Coffee
- $2,000-$3,500 for a cappuccino.
Tipping culture
A 10% service charge is often added in restaurants; check before adding more. Round up small taxi fares. Tipping in cafés is optional but appreciated for table service.
Red
Get the appOfficial public transport app
Prices
- Single ticket
- $770
- Day pass
- None
To the city centre
Terminal de Buses Pajaritos -> Plaza de Armas, Santiago
- Distance
- 11 km
- Travel time
- 20 min
- Use a bip! card or the Red app QR to pay; Red states fares are integrated across bus, Metro and Tren Nos within 120 minutes.
- Bank card contactless works in Metro and Tren Nos under EMV rollout, but buses still commonly require bip! card or Red QR.
FAQs: La Serena to Santiago coach
Find answers to the most common questions about traveling from La Serena to Santiago by coach. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest coach, the cheapest option, or tips for making the most of your visit at Santiago, this guide helps you travel smarter and with confidence.
Cheap coach tickets from La Serena to Santiago can start from as little as £9 when you book in advance. The average coach ticket price for La Serena to Santiago is £16; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by coach from La Serena to Santiago is 5h 40m to travel the 399 km long route. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest coach from La Serena to Santiago leaves at 0:01. Plan your trip with the Journey Planner from Omio.
The latest coach from La Serena to Santiago leaves at 23:50.
Yes, there are 23 direct coaches a day from La Serena to Santiago with FlixBus. Schedules can vary on holidays or weekends with fewer direct coaches.
When taking a coach from La Serena to Santiago, you can count on FlixBus for the best way to get you to Santiago. You can also check all possible coach companies who offer a service between La Serena and Santiago and compare the amenities they offer before buying a coach ticket.
When departing from La Serena , you have various coach station options to start your route from including La Serena, Terminal de buses, Coquimbo, Terminal de Buses . When arriving in Santiago , you can end your route in coach stations like Santiago, Terminal de Buses San Borja, Santiago, Los Libertadores.Passengers board the coach most frequently from La Serena, Terminal de buses, which is located around away from the city centre, and they get off the coach at Santiago, Terminal de Buses San Borja, located 2 away from the city centre.
It's helpful to compare your options as there are 2 ways to travel between La Serena and Santiago including taking a coach and flight.
Yes, there are bathrooms on board the coach from La Serena to Santiago for coach company FlixBus.
Yes, the following accessibility options are available when taking the coach from La Serena to Santiago:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Whether you can cancel your coach ticket from La Serena to Santiago depends on the coach companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the coach with coach company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the coach from La Serena to Santiago.
Yes, the following luggage options are included when booking a coach ticket from La Serena to Santiago:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a coach ticket from La Serena to Santiago:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the coach from La Serena to Santiago. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the coach from La Serena to Santiago with the following coach company: FlixBus
Yes, there are USB plugs on board the coach from La Serena to Santiago with the following coach company: FlixBus.
Yes, there is Wifi on board the coach from La Serena to Santiago with the following coach company: FlixBus.
popular bus stations
Important Stations and Airports in La Serena and Santiago
Most La Serena to Santiago buses use the La Serena, Terminal de buses to Santiago, Terminal de Buses San Borja station pair, with some services arriving at Santiago, Los Libertadores. Use this guide to compare La Serena and Santiago bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in La Serena
Arrival bus stations in Santiago
Which La Serena station do buses to Santiago leave from?
Buses from La Serena to Santiago leave from La Serena, Terminal de buses. The station is from La Serena city centre at La Serena, Coquimbo, Chile.
La Serena, Terminal de busesLa Serena, Coquimbo, Chile
City-centre transport
Getting to La Serena, Terminal de buses from La Serena city centre
BusLa Serena · 2m · every ~11 min
La Serena, Terminal de buses bus station facilities and services
La Serena, Terminal de buses has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower and Ticket Office.
Food and drink
Food options include: Small cafes and food stalls available.
Wi-Fi and ATMs
Free Wi-Fi available in waiting areas. ATMs are aTM machines near the ticket office.
Tickets and information
Ticket office support is available at La Serena, Terminal de buses.
Parking, taxis and toilets
Available at La Serena, Terminal de buses: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at La Serena, Terminal de buses: Wheelchair ramps and accessible restrooms present.
Which Santiago station do buses from La Serena arrive at?
Buses from La Serena to Santiago most often arrive at Santiago, Terminal de Buses San Borja. Some services arrive at Santiago, Los Libertadores, so check your ticket before travel to confirm your Santiago arrival station.
Santiago, Terminal de Buses San BorjaTerminal de Buses San Borja - San Francisco de Borja 184, 9160018 Estación Central, Santiago, Región Metropolitana, Chile
City-centre transport
Getting to Santiago, Terminal de Buses San Borja from Santiago city centre
Santiago, Terminal de Buses San Borja is 2 km from Santiago city centre. Public transport options include:
Bus510 · 12m · £0.90 · every ~10 min
510 · 13m · £0.90 · every ~10 min
SubwayL1 · 7m · £0.90 · every ~44 min
Santiago, Terminal de Buses San Borja bus station facilities and services
Santiago, Terminal de Buses San Borja has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower and Ticket Office.
Food and drink
Food options include: Several fast food and traditional eateries are available.
Wi-Fi and ATMs
Free Wi-Fi available inside terminal. ATMs are several ATMs located within the terminal.
Tickets and information
Ticket office support is available at Santiago, Terminal de Buses San Borja.
Parking, taxis and toilets
Available at Santiago, Terminal de Buses San Borja: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santiago, Terminal de Buses San Borja: Wheelchair accessible entrances and exits available.
Santiago, Los LibertadoresHuechuraba 2020, 2020, Conchalí, Quilicura, Región Metropolitana, Chile
City-centre transport
Getting to Santiago, Los Libertadores from Santiago city centre
Santiago, Los Libertadores is 10 km from Santiago city centre. Public transport options include:
BusFlixBus CL040, FlixBus CL006 · 30m · £0.90 · every ~2 min
201, 264n · 59m · £0.90 · every ~17 min
214 · 1h 3m · £0.90 · every ~11 min
SubwayL3 · 20m · £0.90 · every ~24 min
Santiago, Los Libertadores bus station facilities and services
Santiago, Los Libertadores has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower and Ticket Office.
Food and drink
Food options include: Several fast food outlets and cafes are available.
Wi-Fi and ATMs
Free Wi-Fi is available throughout the station. ATMs are aTMs are located near the ticket office.
Tickets and information
Ticket office support is available at Santiago, Los Libertadores.
Parking, taxis and toilets
Available at Santiago, Los Libertadores: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santiago, Los Libertadores: The station is wheelchair accessible.
Most popular buses to and from Santiago and La Serena
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