- Must visit
Pinacoteca di Brera
One of Milan’s leading art museums, with Italian masterpieces from the Middle Ages to the 20th century in a historic palace.
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The cheapest and fastest coaches from Isernia to Milan
Showing times, prices and bookable tickets for 18 Sept
Cheapest price on 18 Sept
£21
Average ticket price on 18 Sept
£28
Fastest journey on 18 Sept
12 h 14 m
Average journey duration on 18 Sept
12 h 54 m
Buses on 18 Sept
3
Distance
592 km
Cheap tickets
The best way to find a cheap coach ticket from Isernia to Milan is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from Isernia to Milan will cost around £28 if you buy it on the day, but you can find cheap coach tickets today for only £21.
Fast coaches
On Fri 18 Sept, we found 3 buses from Isernia to Milan, including 3 direct services.
These direct buses cover the 592 km distance in an average of 12 h 54 m but if you time it right, some buses will get you there in just 12 h 14 m .
The slowest buses will take 14 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
14:5014h15Isernia5:05Milan£211One-way0 changes- 10:4512h14Isernia22:59Milan£251One-way0 changes
- 9:4512h14Isernia21:59Milan£381One-way0 changes
- 10:4512h14Isernia22:59Milan£251One-way0 changes
- 9:4512h14Isernia21:59Milan£381One-way0 changes
- 14:5014h15Isernia5:05Milan£211One-way0 changes
Travel Information
Compare train, coach and flight for Isernia to Milan
Omio recommends booking the train as it is the most popular option from Isernia to Milan among Omio's users. If you are prioritising price, take the train, with an average ticket price of £45 For those with little time, consider booking a flight, which has an average total journey time of 3h 25m. Average ticket prices depend on the travel mode: a train costs an average of £45, while a flight costs an average of £60.
Distance: 592 km
Compare bus with
| Coach | Most popular Train | Flight | Driving |
|---|---|---|---|
£48 Average Price | £45 Average Price Cheapest | £60 Average Price | £154 Average Price (fuel + tolls) |
11h 41m Average total duration 11h 11m Onboard + 30m Additional time* | 8h 2m Average total duration 7h 32m Onboard + 30m Additional time* | 3h 25m Average total duration Fastest 1h 25m Onboard + 2h 0m Additional time* | 7h 54m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Isernia to Milan is a train with an average price of £45.
This is compared to other travel options from Isernia to Milan:
A train is £3 less than a coach for this route with tickets for a coach from Isernia to Milan costing on average £48.
A train is £15 less than a flight for this route with tickets for a flight from Isernia to Milan costing on average £60.
The fastest way to travel from Isernia to Milan is by flight with an average journey time of 1h 25m.
Other travel options to Milan take longer:
Train takes on average 7h 32m.
Coach takes on average 11h 11m.
It's helpful to compare your options as there are 3 ways to travel between Isernia and Milan including taking a train, coach and flight.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around £48 compared to roughly £154 in fuel and tolls — a saving of about £105. The journey takes 11h 11m versus 7h 54m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Live departures
Isernia to Milan bus times
The table below shows live departures for Isernia to Milan coaches for today, Thursday 17 September. You can also manually refresh the results below to see updated coach journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
| 9:45 Isernia | 12h14 | 21:59 Milan | 0 changesdirect | |
| 16:05 Isernia | 14h00 | 6:05 Milan | 0 changesdirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Isernia to Milan by train, coach or flight
Compare train, coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Fri
18 Sept
18 Sept
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19 Sept
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20 Sept
20 Sept
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21 Sept
21 Sept
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22 Sept
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24 Sept
24 Sept
Why should you book Isernia to Milan coaches with Omio?
FlixBus as well as ATM Azienda di Trasporti Molisana S.p.A. offer coaches services from Isernia to Milan.
Omio is an official ticket reseller for all your travel options from Isernia to Milan.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of ATM Azienda di Trasporti Molisana S.p.A. to find the best option for your trip from Isernia to Milan.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Isernia to Milan.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Isernia to Milan.
Journey information
Overview: Bus from Isernia to Milan
ItalyItaly
Buses from Isernia to Milan run on average 11 times per day, taking around 11h 11m. Cheap bus tickets for this journey start at £42 but you can travel from only £29 by train.
There are 2 coaches per day. The earliest coach runs at 00:30, the last at 23:50. The fastest coach covers the 592 km distance in 11h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from £29
Distance 592 km |
Average bus duration 11h 11m |
Cheapest ticket price £42 |
Buses per day 11 |
Direct buses 2 |
Fastest bus 11h 25m |
First bus 0:30 |
Last bus 23:50 |
Cheapest Month Feb |
Cheapest Day Tue |
High Season Jul - Sept |
Low Season Apr - Jun |
Busiest Day Tue |
Least Busy Day Tue |
Best time to book 21 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from £29
Bus providers: FlixBus, ATM Azienda di Trasporti Molisana S.p.A. from Isernia to MilanYou can travel by bus between Isernia to Milan with FlixBus, ATM Azienda di Trasporti Molisana S.p.A. for as low as £29. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
13h 5m
Cheapest FlixBus Price
£42
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
ATM Azienda di Trasporti Molisana S.p.A.
Luggage & cancellation policy
Average ATM Azienda di Trasporti Molisana S.p.A. Duration
11h 30m
Cheapest ATM Azienda di Trasporti Molisana S.p.A. Price
£64
ATM Azienda di Trasporti Molisana S.p.A. frequency
1 a day
Bus providers: FlixBus, ATM Azienda di Trasporti Molisana S.p.A. from Isernia to MilanYou can travel by bus between Isernia to Milan with FlixBus, ATM Azienda di Trasporti Molisana S.p.A. for as low as £29. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
13h 5m
Cheapest FlixBus Price
£42
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
ATM Azienda di Trasporti Molisana S.p.A.
Luggage & cancellation policy
Average ATM Azienda di Trasporti Molisana S.p.A. Duration
11h 30m
Cheapest ATM Azienda di Trasporti Molisana S.p.A. Price
£64
ATM Azienda di Trasporti Molisana S.p.A. frequency
1 a day
Complete guide to Milan
Things to do in Milan
Discover the best of Milan — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milan trip today.
- Must visit
Cenacolo Vinciano
The museum visit centres on Leonardo’s Last Supper, one of the city’s most sought-after cultural experiences.
- Recommended
Museo Nazionale della Scienza e della Tecnologia Leonardo da Vinci
A science and technology museum with Leonardo galleries, transport exhibits and hands-on displays in a former monastery.
- Must visit
Piazza del Duomo
Milan’s central square is the city’s main meeting point, framed by the cathedral, museums and lively pedestrian spaces.
- Must visit
Navigli
This redeveloped canal district is popular for waterside walks, old railings, independent shops and a lively Milan atmosphere.
- Recommended
Quadrilatero del Silenzio
A refined district of elegant streets, Liberty villas and designer shops, ideal for architecture lovers and quieter walks.
- Vegetarian
- Gluten-free
Risotto alla Milanese
Saffron risotto cooked to a creamy texture with butter and cheese. A signature Milanese dish linked to Lombardy’s love of rich, elegant rice dishes.
Cotoletta alla Milanese
Breaded veal cutlet fried in butter until crisp. One of Milan’s best-known classics, traditionally served bone-in and prized for its simple, rich flavour.
- Gluten-free
Ossobuco
Slow-braised veal shanks, often with vegetables and wine, usually served with risotto. A historic Lombard comfort dish known for tender meat and marrow.
Cracco
Refined two-Michelin-star dining by Carlo Cracco in an elegant setting inside Galleria Vittorio Emanuele II. Known for modern Italian tasting menus.
Antica Trattoria della Pesa
Historic Milanese restaurant famed for ossobuco and Risotto alla Milanese. Formal, old-school atmosphere with strong ties to local culinary tradition.
Trattoria Milanese
Traditional trattoria celebrated for classic Milanese dishes including cotoletta and cassoeula. Warm, established venue with a loyal local following.
Euro (€)
Moderate for Italy: hotels and dining run higher than many cities, but public transport is affordable and budget eats are easy to find.
Average meal costs
- Budget
- €8-15 for fast food or street food.
- Mid-range
- €20-40 per person for a meal.
- Fine dining
- €70+ per person for upscale restaurants.
- Coffee
- €1.20-2.50 for espresso or cappuccino.
Tipping culture
Service is often included or modest. Round up or leave €1-2 in cafés, 5-10% in restaurants for good service, and round up taxi fares.
ATM Milano Official App
Get the appOfficial public transport app
Prices
- Single ticket
- € 2.20
- Day pass
- € 7.60
To the city centre
Orio al Serio, Milan Bergamo Airport (Bus station) -> Milano Stazione Centrale FS, Milan
- Distance
- 3 km
- Travel time
- 10 min
Best option: Airport Coach to Milano Stazione Centrale FS
- Price
- /
- Duration
- 50 min
- Contactless bank cards and devices work on the metro and on some buses, so you can pay as you go without buying a paper ticket first.
- Use the ATM Milano Official App to buy tickets, check waiting times, and plan routes with real-time service updates.
FAQs: Isernia to Milan coach
Find answers to the most common questions about traveling from Isernia to Milan by coach. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest coach, the cheapest option, or tips for making the most of your visit at Milan, this guide helps you travel smarter and with confidence.
Cheap coach tickets from Isernia to Milan can start from as little as £42 when you book in advance. The average coach ticket price for Isernia to Milan is £48; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by coach from Isernia to Milan is 11h 25m to travel the 592 km long route. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest coach from Isernia to Milan leaves at 0:30. Plan your trip with the Journey Planner from Omio.
The latest coach from Isernia to Milan leaves at 23:50.
Yes, there are 2 direct coaches a day from Isernia to Milan with . Schedules can vary on holidays or weekends with fewer direct coaches.
When taking a coach from Isernia to Milan, you can count on FlixBus, ATM Azienda di Trasporti Molisana S.p.A. for the best way to get you to Milan. You can also check all possible coach companies who offer a service between Isernia and Milan and compare the amenities they offer before buying a coach ticket.
When departing from Isernia , you have various coach station options to start your route from including Isernia, Piazza della Repubblica (F. Martino bus station) . When arriving in Milan , you can end your route in coach stations like Milano, Autostazione Lampugnano, Milano, San Donato - Settore B (Viale Giuseppe Impastato), Milano, Milan Linate Airport, Assago, Viale Milanofiori (Assago M2), Sesto San Giovanni, Piazza Primo Maggio (Stazione ferroviaria), Cormano, A4 (Cusano Milanino West).Passengers board the coach most frequently from Isernia, Piazza della Repubblica (F. Martino bus station), which is located around away from the city centre, and they get off the coach at Milano, Autostazione Lampugnano, located 5 away from the city centre.
A trip to Milan from Isernia is worth doing but not as a day trip with a journey time of 11h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a coach from Isernia to Milan is February.
It's helpful to compare your options as there are 3 ways to travel between Isernia and Milan including taking a train, coach and flight.
Yes, the following accessibility options are available when taking the coach from Isernia to Milan:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the coach from Isernia to Milan for coach company FlixBus.
Whether you can cancel your coach ticket from Isernia to Milan depends on the coach companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the coach with coach company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the coach from Isernia to Milan.
Yes, the following luggage options are included when booking a coach ticket from Isernia to Milan:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a coach ticket from Isernia to Milan:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the coach from Isernia to Milan. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the coach from Isernia to Milan with the following coach company: FlixBus
Yes, there are USB plugs on board the coach from Isernia to Milan with the following coach company: FlixBus.
Yes, there is Wifi on board the coach from Isernia to Milan with the following coach company: FlixBus.
popular bus stations
Important Stations and Airports in Isernia and Milan
Most Isernia to Milan buses use the Isernia, Piazza della Repubblica (Autostazione F. Martino) to Milano, Autostazione Lampugnano station pair, with some services arriving at Milano, San Donato - Settore B (Viale Giuseppe Impastato). Use this guide to compare Isernia and Milan bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Isernia
Arrival bus stations in Milan
Which Isernia station do buses to Milan leave from?
Buses from Isernia to Milan leave from Isernia, Piazza della Repubblica (Autostazione F. Martino). The station is from Isernia city centre at Isernia Piazza della Repubblica, 86170 Isernia IS, Italy.
Isernia, Piazza della Repubblica (Autostazione F. Martino)Isernia Piazza della Repubblica, 86170 Isernia IS, Italy
City-centre transport
Getting to Isernia, Piazza della Repubblica (Autostazione F. Martino) from Isernia city centre
TRUE
Isernia, Piazza della Repubblica (Autostazione F. Martino) bus station facilities and services
Isernia, Piazza della Repubblica (Autostazione F. Martino) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower and Ticket Office.
Food and drink
Food options include: Nearby cafés and fast food outlets.
Wi-Fi and ATMs
Wi-Fi is available at Isernia, Piazza della Repubblica (Autostazione F. Martino). ATMs are aTM located near the entrance.
Tickets and information
Ticket office support is available at Isernia, Piazza della Repubblica (Autostazione F. Martino).
Parking, taxis and toilets
Available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Wheelchair accessible facility.
Which Milan station do buses from Isernia arrive at?
Buses from Isernia to Milan most often arrive at Milano, Autostazione Lampugnano. Some services arrive at Milano, San Donato - Settore B (Viale Giuseppe Impastato), so check your ticket before travel to confirm your Milan arrival station.
Milano, Autostazione LampugnanoVia Giulio Natta, 226, 20151 Milano MI, Italy
City-centre transport
Getting to Milano, Autostazione Lampugnano from Milan city centre
Milano, Autostazione Lampugnano is 5 km from Milan city centre. Public transport options include:
BusNm1 · 19m · £2 · every ~2 min
Subway1 · 13m · £2 · every ~18 min
Milano, Autostazione Lampugnano bus station facilities and services
Milano, Autostazione Lampugnano has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC and Ticket Office.
Food and drink
Food options include: Cafeteria Lampugnano (in the station), Trattoria Milano (0.5 km), Pizza Express (0.7 km).
Wi-Fi and ATMs
Free Wi-Fi. ATMs are located near the main entrance.
Tickets and information
Ticket office support is available at Milano, Autostazione Lampugnano.
Parking, taxis and toilets
Available at Milano, Autostazione Lampugnano: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Milano, Autostazione Lampugnano: Elevators, ramps.
Milano, San Donato - Settore B (Viale Giuseppe Impastato)Viale Giuseppe Impastato, Milano, Italy
City-centre transport
Getting to Milano, San Donato - Settore B (Viale Giuseppe Impastato) from Milan city centre
Milano, San Donato - Settore B (Viale Giuseppe Impastato) is 6 km from Milan city centre. Public transport options include:
Bus121, 132 · 18m · £2 · every ~14 min
132 · 20m · £2 · every ~5 min
Milano, San Donato - Settore B (Viale Giuseppe Impastato) bus station facilities and services
Milano, San Donato - Settore B (Viale Giuseppe Impastato) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC and Ticket Office.
Food and drink
Food options include: Cafeteria Italiana (in the station), Fast Food Express (in the station), Trattoria Milano (0.5 km).
Wi-Fi and ATMs
Free Wi-Fi. ATMs are located near the main entrance for cash withdrawals.
Tickets and information
Ticket office support is available at Milano, San Donato - Settore B (Viale Giuseppe Impastato).
Parking, taxis and toilets
Available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Elevators, ramps.
Milano, Aeroporto di Milano Linate
City-centre transport
Getting to Milano, Aeroporto di Milano Linate from Milan city centre
Bus973 · 15m · £2 · every ~5 min
Autostradale 144 · 25m · £0.90 · every ~3 min
flibco · 25m · £2 · every ~2 min
Subway4 · 12m · £2 · every ~30 min
More options for your journey from Isernia to Milan
Here are some other resources that might have the information you need
Most popular buses to and from Milan and Isernia
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