The cheapest and fastest coaches from Siena to Brindisi
Cheapest price
£18
Average price
£64
Fastest journey
10 h 40 m
Average duration
11 h 23 m
Buses per day
19
Distance
622 km
The best way to find a cheap coach ticket from Siena to Brindisi is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from Siena to Brindisi will cost around £64 if you buy it on the day, but you can find cheap coach tickets today for only £18.
Of the 19 buses that leave Siena for Brindisi every day 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
These direct buses cover the 622 km distance in an average of 11 h 23 m but if you time it right, some buses will get you there in just 10 h 40 m .
The slowest buses will take 11 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2401 · 1107
2490 · 2203
2401 · 1225
3825 · 1109
2495 · 1109
1121
207
FlixBus · FlixBus
FlixBus · FlixBus
3825 · 1109Travel Information
Compare train, coach and flight for Siena to Brindisi
Omio recommends booking the coach as it is the most popular option from Siena to Brindisi among Omio's users. If you are prioritising price take the coach with prices starting from £14. For those with little time consider booking a flight which can get you there in 4h 32m. The ticket price range depends on the travel mode: a coach costs an average of £14, and a flight costs an average of £18.
Distance: 622 km
Compare bus with
Most popular Coach | Train | Flight |
|---|---|---|
£35 Average Price Cheapest | £72 Average Price | £92 Average Price |
11h 31m Average total duration 11h 1m Onboard + 30m Additional time* | 10h 31m Average total duration 10h 1m Onboard + 30m Additional time* | 7h 32m Average total duration Fastest 4h 32m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Siena to Brindisi bus times
The table below shows live departures for Siena to Brindisi coaches for today, Friday 5 December. You can also manually refresh the results below to see updated coach journeys.
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
3825 · 1109 | 05:05 Siena, Stazione FS (Piazzale Carlo Rosselli) | 11h55 | 17:00 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
FlixBus · FlixBus · FlixBus | 06:05 Siena, P.za Gramsc | 14h35 | 20:40 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 changes | |
FlixBus · FlixBus · FlixBus | 06:15 Siena, Stazione FS (Piazzale Carlo Rosselli) | 14h25 | 20:40 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 changes | |
FlixBus · FlixBus · FlixBus | 06:25 Siena, Siena/Viale Pietro Toselli | 14h15 | 20:40 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 changes | |
1121 | 08:00 Siena, Stazione FS (Piazzale Carlo Rosselli) | 10h40 | 18:40 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 0 changesdirect | |
207 | 10:05 Siena, Stazione FS (Piazzale Carlo Rosselli) | 11h05 | 21:10 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 0 changesdirect | |
FlixBus · FlixBus · FlixBus | 13:51 Siena, Siena/Viale Pietro Toselli | 16h24 | 06:15 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 changes | |
FlixBus · FlixBus | 17:25 Siena, Stazione FS (Piazzale Carlo Rosselli) | 11h45 | 05:10 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
2490 · 2203 | 17:35 Siena, Stazione FS (Piazzale Carlo Rosselli) | 15h25 | 09:00 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
2401 · 1225 | 17:50 Siena, Stazione FS (Piazzale Carlo Rosselli) | 13h40 | 07:30 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
2401 · 1107 | 17:50 Siena, Stazione FS (Piazzale Carlo Rosselli) | 12h40 | 06:30 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
FlixBus · FlixBus | 18:45 Siena, Stazione FS (Piazzale Carlo Rosselli) | 14h20 | 09:05 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
108 | 19:30 Siena, Stazione FS (Piazzale Carlo Rosselli) | 11h55 | 07:25 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 0 changesdirect | |
FlixBus · FlixBus · FlixBus | 20:45 Siena, Siena/Viale Pietro Toselli | 15h40 | 12:25 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 changes | |
FlixBus · FlixBus · FlixBus | 21:25 Siena, Stazione FS (Piazzale Carlo Rosselli) | 15h00 | 12:25 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 changes | |
FlixBus · FlixBus · FlixBus | 23:45 Siena, Stazione FS (Piazzale Carlo Rosselli) | 16h00 | 15:45 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 changes | |
| Saturday 6 December | |||||
1801 · 1103 | 03:00 Siena, Stazione FS (Piazzale Carlo Rosselli) | 12h35 | 15:35 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
2495 · 1109 | 04:15 Siena, Stazione FS (Piazzale Carlo Rosselli) | 12h45 | 17:00 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
FlixBus · FlixBus | 04:35 Siena, Stazione FS (Piazzale Carlo Rosselli) | 12h50 | 17:25 Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 change | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Siena to Brindisi by train, coach or flight
Compare train, coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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12 Dec
Journey information
Overview: Bus from Siena to Brindisi
Buses from Siena to Brindisi run on average 14 times per day, taking around 11h 1m. Cheap bus tickets for this journey start at £14 if you book in advance.
There are 2 coaches per day. The earliest coach runs at 00:05, the last at 23:39. The fastest coach covers the 622 km distance in 10h 40m.
Distance 622 km |
Average bus duration 11h 1m |
Cheapest ticket price £14 |
Buses per day 14 |
Direct buses 2 |
Fastest bus 10h 40m |
First bus 00:05 |
Last bus 23:39 |
Bus providers: Marino Autolinee, Itabus, FlixBus from Siena to BrindisiYou can travel by bus between Siena to Brindisi with Marino Autolinee, Itabus, FlixBus for as low as £14. When you search for schedules and tickets, Omio will show you the best journey
Marino Autolinee
Itabus
FlixBus
FAQs: Siena to Brindisi coach
Find answers to the most common questions about traveling from Siena to Brindisi by coach. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest coach, the cheapest option, or tips for making the most of your visit at Brindisi, this guide helps you travel smarter and with confidence.

Passengers board the coach most frequently from Siena, Stazione FS (Piazzale Carlo Rosselli), which is located around 1.5 miles (2.4 km) away from the city centre, and they get off the coach at Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale), located 0.6 miles (1 km) away from the city centre.
To find the cheapest bus tickets for your trip from Siena to Brindisi, follow these tips:
Start your search now and compare ticket prices to find the best deal!
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