The cheapest and fastest coaches from Siena to Brindisi
Cheapest price
£24
Average price
£44
Fastest journey
10 h 40 m
Average duration
12 h 23 m
Buses per day
4
Distance
622 km
The best way to find a cheap coach ticket from Siena to Brindisi is to book your journey as far in advance as possible and to avoid travelling at rush hour.
The average ticket from Siena to Brindisi will cost around £44 if you buy it on the day, but you can find cheap coach tickets today for only £24.
Of the 4 buses that leave Siena for Brindisi every day 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
These direct buses cover the 622 km distance in an average of 12 h 23 m but if you time it right, some buses will get you there in just 10 h 40 m .
The slowest buses will take 14 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Travel Information
Compare train, coach and flight for Siena to Brindisi
Omio recommends booking the coach as it is the most popular option from Siena to Brindisi among Omio's users. If you are prioritising price take the coach with prices starting from £18. For those with little time consider booking a flight which can get you there in 1h 30m. The ticket price range depends on the travel mode: a coach costs an average of £18, and a flight costs an average of £18.
Distance: 622 km
Compare bus with
Most popular Coach | Flight | Train |
|---|---|---|
£43 Average Price Cheapest | £120 Average Price | £80 Average Price |
11h 27m Average total duration 10h 57m Onboard + 30m Additional time* | 4h 30m Average total duration Fastest 1h 30m Onboard + 3h 0m Additional time* | 8h 52m Average total duration 8h 22m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company |
Direct Options | Direct Options | Direct Options |
Live departures
Siena to Brindisi bus times
The table below shows live departures for Siena to Brindisi coaches for today, Thursday 5 March. You can also manually refresh the results below to see updated coach journeys.
| Provider | Departs | Duration | Arrives | Changes | Tickets |
|---|---|---|---|---|---|
![]() | 17:35 Siena | 15h25 | 09:00 Brindisi | 0 changesdirect | |
![]() | 21:25 Siena | 15h00 | 12:25 Brindisi | 0 changesdirect | |
| Friday 6 March | |||||
![]() | 08:00 Siena | 10h40 | 18:40 Brindisi | 0 changesdirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Siena to Brindisi by train, coach or flight
Compare train, coach and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
06 Mar
07 Mar
08 Mar
09 Mar
10 Mar
11 Mar
12 Mar
Why should you book Siena to Brindisi coaches with Omio?
Why book with Omio vs Marino Autolinee?
- Compare with other providers: On Omio, you can not only buy tickets for Marino Autolinee, but also compare tickets for the likes of Itabus or FlixBus to find the best option for your trip from Siena to Brindisi.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Marino Autolinee with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Siena to Brindisi.
Why book with Omio over Checkmybus, Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus or FlixBus to find the best option for your trip from Siena to Brindisi.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Siena to Brindisi.
Journey information
Overview: Bus from Siena to Brindisi
Buses from Siena to Brindisi run on average 14 times per day, taking around 10h 57m. Cheap bus tickets for this journey start at £18 but you can travel from only £18 by flight.
There are 2 coaches per day. The earliest coach runs at 00:05, the last at 23:39. The fastest coach covers the 622 km distance in 10h 40m.
Distance 622 km |
Average bus duration 10h 57m |
Cheapest ticket price £18 |
Buses per day 14 |
Direct buses 2 |
Fastest bus 10h 40m |
First bus 00:05 |
Last bus 23:39 |
Bus providers: Marino Autolinee, Itabus, FlixBus from Siena to BrindisiYou can travel by bus between Siena to Brindisi with Marino Autolinee, Itabus, FlixBus for as low as £18. When you search for schedules and tickets, Omio will show you the best journey
Marino Autolinee
Itabus
FlixBus
FAQs: Siena to Brindisi coach
Find answers to the most common questions about traveling from Siena to Brindisi by coach. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest coach, the cheapest option, or tips for making the most of your visit at Brindisi, this guide helps you travel smarter and with confidence.

- Marino Autolinee
- Assistance
- Priority seating
- Accessible restrooms.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- Marino Autolinee
- You can cancel your ticket up to 24 hours before departure for a full refund. Cancellations within 24 hours incur a 50% fee.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
- Marino Autolinee
- One carry-on bag up to 10kg (55x40x20 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- Marino Autolinee
- 10€ per additional bag up to 20 kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- Marino Autolinee
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
popular bus stations
Important Stations and Airports in Siena and Brindisi
Most popular bus connections from Siena
More options for your journey from Siena to Brindisi
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